Name Steward Organization Suggested Domain Suggested Domain Description Cde Group Classification
Family history medical condition type NINDS Disease characterization
Including Alzheimer's Disease (AD)/AD-Related Dementias (ADRD) diagnosis and multiple chronic conditions (MCCs)
NIH CDEs
  • NINDS
    • Disease
      • Amyotrophic Lateral Sclerosis
        • Classification
          • Core
        • Domain
          • Participant History and Family History
            • General Health History
      • Cerebral Palsy
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Congenital Muscular Dystrophy
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Duchenne/Becker Muscular Dystrophy
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Facioscapulohumeral muscular dystrophy (FSHD)
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Friedreich's Ataxia
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • General (For all diseases)
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Headache
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Huntington’s Disease
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Multiple Sclerosis
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Myasthenia Gravis
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Myotonic Dystrophy
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Spinal Cord Injury
        • Classification
          • Exploratory
        • Domain
          • Participant History and Family History
            • General Health History
      • Spinal Muscular Atrophy
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Stroke
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
      • Unruptured Cerebral Aneurysms and Subarachnoid Hemorrhage
        • Classification
          • Supplemental
        • Domain
          • Participant History and Family History
            • General Health History
    • Domain
      • Participant History and Family History
        • General Health History
    • Population
      • Adult
      • Pediatric

# Datatype
Value List

# Permissible value Value meaning name Value meaning definition
(Pre)eclampsia (Pre)eclampsia (Pre)eclampsia
Abdominal aortic aneurysm Abdominal aortic aneurysm Abdominal aortic aneurysm
Acute coronary syndrome Acute coronary syndrome Acute coronary syndrome
Alcohol use disorder Alcohol use disorder Alcohol use disorder
Allerg(ies) Allerg(ies) Allerg(ies)
Alpha 7 integrin CMD Alpha 7 integrin CMD Alpha 7 integrin congenital muscular dystrophy
Alzheimer's disease Alzheimer's disease Alzheimer's disease
Amyotrophic lateral sclerosis (ALS) Amyotrophic lateral sclerosis (ALS) Amyotrophic lateral sclerosis (ALS)
Anorexia Anorexia Anorexia
Anxiety Anxiety Anxiety
Arterial dissection Arterial dissection Arterial dissection
Arthritis Arthritis Arthritis
Asthma Asthma Asthma
Ataxia Ataxia Ataxia
Autism Autism Autism
Bi-polar disorder Bi-polar disorder Bi-polar disorder
Binge eating Binge eating Binge eating
Bleeding disorder Bleeding disorder Bleeding disorder
Blindness Blindness Blindness
Brain aneurysm Brain aneurysm Brain aneurysm
Bulimia Bulimia Bulimia
CAG expansion but not diagnosed CAG expansion but not diagnosed CAG expansion but not diagnosed
Cancer Cancer Cancer
Cardiomyopathy Cardiomyopathy Cardiomyopathy
Cerebral aneurysm Cerebral aneurysm Cerebral aneurysm
Cerebral palsy Cerebral palsy Cerebral palsy
Child-onset diseases Child-onset diseases Child-onset diseases
Chronic ataxia Chronic ataxia Chronic ataxia
Clotting disorder Clotting disorder Clotting disorder
CMD, undiagnosed CMD, undiagnosed CMD, undiagnosed
Collagen VI CMD Collagen VI CMD Collagen VI CMD
Contractures Contractures Contractures
Coronary artery disease Coronary artery disease Coronary artery disease
Coronary vascular disease Coronary vascular disease Coronary vascular disease
Deafness Deafness Deafness
Dementia Dementia Dementia
Depression Depression Depression
Developmental delays Developmental delays Developmental delays
Diabetes mellitus Diabetes mellitus Diabetes mellitus
Difficulty walking Difficulty walking Difficulty walking
Duchenne or Becker Muscular Dystrophy Duchenne or Becker Muscular Dystrophy Duchenne or Becker Muscular Dystrophy
Dyslipidemia Dyslipidemia Dyslipidemia
Dystonia Dystonia Dystonia
Dystroglycanopathy Dystroglycanopathy Dystroglycanopathy
Early childhood death Early childhood death Early childhood death
Early onset neural degeneration (loss of skills) Early onset neural degeneration (loss of skills) Early onset neural degeneration (loss of skills)
Eczema Eczema Eczema
Ehlers-Danlos Syndrome Type IV Ehlers-Danlos Syndrome Type IV Ehlers-Danlos Syndrome Type IV
Emotional/Verbal abuse Emotional/Verbal abuse Emotional/Verbal abuse
Endometriosis Endometriosis Endometriosis
Epilepsy Epilepsy Epilepsy
Extracranial aneurysm Extracranial aneurysm Extracranial aneurysm
Fibromyalgia Fibromyalgia Fibromyalgia
Friedreich's ataxia Friedreich's ataxia Friedreich's ataxia
Frontotemporal dementia (FTD) Frontotemporal dementia (FTD) Frontotemporal dementia (FTD)
Gastroparesis Gastroparesis Gastroparesis
HD diagnosed HD diagnosed HD diagnosed
Headaches Headaches Headaches
Heart disease Heart disease Heart disease
Hemorrhagic stroke Hemorrhagic stroke Hemorrhagic stroke
Hereditary hemorrhagic telangiectasia (HHT) Hereditary hemorrhagic telangiectasia (HHT) Hereditary hemorrhagic telangiectasia (HHT)
Hypertension Hypertension Hypertension
Hypotension Hypotension Hypotension
Illicit substance use disorder Illicit substance use disorder Illicit substance use disorder
Insomnia Insomnia Insomnia
Intellectual disability Intellectual disability Intellectual disability
Intellectual disability or mental retardation Intellectual disability or mental retardation Intellectual disability or mental retardation
Interstitial Cystitis Interstitial Cystitis Interstitial Cystitis
Intracerebral hemorrhage Intracerebral hemorrhage Intracerebral hemorrhage
Intracranial vascular malformation Intracranial vascular malformation Intracranial vascular malformation
Irritable bowel syndrome (IBS) Irritable bowel syndrome (IBS) Irritable bowel syndrome (IBS)
Ischemic Stroke Ischemic Stroke Ischemic Stroke
Known genetic syndrome Known genetic syndrome Known genetic syndrome
L-CMD L-CMD L-CMD
Learning disability Learning disability Learning disability
Marfan Syndrome Marfan Syndrome Marfan Syndrome
Memory loss Memory loss Memory loss
Merosin deficient CMD Merosin deficient CMD Merosin deficient CMD
Migraines Migraines Migraines
Miscarriages and pregnancy-related complications Miscarriages and pregnancy-related complications Miscarriages and pregnancy-related complications
Mitochondrial disease Mitochondrial disease Mitochondrial disease
Mitochondrial disorders Mitochondrial disorders Mitochondrial disorders
Mitral valve prolapse Mitral valve prolapse Mitral valve prolapse
Multiple endocrine neoplasia type I Multiple endocrine neoplasia type I Multiple endocrine neoplasia type I
Multiple miscarriages Multiple miscarriages Multiple miscarriages
Multiple sclerosis Multiple sclerosis Multiple sclerosis
Muscle disease Muscle disease Muscle disease
Muscle disease (not Duchenne or Becker muscular dystrophy) Muscle disease (not Duchenne or Becker muscular dystrophy) Muscle disease (not Duchenne or Becker muscular dystrophy)
Muscle disease: acquired or postnatal onset Muscle disease: acquired or postnatal onset Muscle disease: acquired or postnatal onset
Muscle disease: Congenital Muscle disease: Congenital Muscle disease: Congenital
Muscle weakness Muscle weakness Muscle weakness
Myasthenia gravis Myasthenia gravis Myasthenia gravis
Narcolepsy Narcolepsy Narcolepsy
Neurofibromatosis type 1 (NF1) Neurofibromatosis type 1 (NF1) Neurofibromatosis type 1 (NF1)
Neuromuscular disease Neuromuscular disease Neuromuscular disease
Neuromuscular junction Neuromuscular junction Neuromuscular junction
Neuromuscular junction: Congenital Neuromuscular junction: Congenital Neuromuscular junction: Congenital
Neuromuscular junction: Postnatal onset Neuromuscular junction: Postnatal onset Neuromuscular junction: Postnatal onset
Neuropathy Neuropathy Neuropathy
No neurological diagnosis No neurological diagnosis No neurological diagnosis
Obesity Obesity Obesity
Obsessive-compulsive disorder (OCD) Obsessive-compulsive disorder (OCD) Obsessive-compulsive disorder (OCD)
Other Immunological Disorders, specify: Other Immunological Disorders, specify: Other Immunological Disorders, specify:
Other neurological disorder, specify Other neurological disorder, specify Other neurological disorder, (specify)
Other Sleep condition, specify Other Sleep condition, specify Other Sleep condition, specify
Other, specify Other, specify Other, specify
Painful bladder Painful bladder Painful bladder
Parkinson's disease Parkinson's disease Parkinson's disease
Patent-Foramen Ovale (PFO)/Right-left shunt (RLS) Patent-Foramen Ovale (PFO)/Right-left shunt (RLS) Patent-Foramen Ovale (PFO)/Right-left shunt (RLS)
Peripheral neuropathy Peripheral neuropathy Peripheral neuropathy
Periphereal vascular disease Periphereal vascular disease Periphereal vascular disease
Physical abuse Physical abuse Physical abuse
Polycystic kidney disease Polycystic kidney disease Polycystic kidney disease
Polycystic ovary syndrome Polycystic ovary syndrome Polycystic ovary syndrome
Post traumatic stress disorder (PTSD) Post traumatic stress disorder (PTSD) Post traumatic stress disorder (PTSD)
Prescription use disorder Prescription use disorder Prescription use disorder
Psychiatric illness Psychiatric illness Psychiatric illness
Restless leg syndrome (RLS) Restless leg syndrome (RLS) Restless leg syndrome (RLS)
Reynaud's Syndrome Reynaud's Syndrome Reynaud's Syndrome
Rheumatoid arthritis Rheumatoid arthritis Rheumatoid arthritis
Schizophrenia Schizophrenia Schizophrenia
Seizures without diagnosis of epilepsy Seizures without diagnosis of epilepsy Seizures without diagnosis of epilepsy
SEPN1 related myopathy (Rigid spine) SEPN1 related myopathy (Rigid spine) SEPN1 related myopathy (Rigid spine)
Sexual abuse Sexual abuse Sexual abuse
Sleep apnea Sleep apnea Sleep apnea
Spinal muscular atrophy (SMA) Spinal muscular atrophy (SMA) Spinal muscular atrophy (SMA)
Stroke Stroke Stroke
Subarachnoid hemorrhage (SAH) Subarachnoid hemorrhage (SAH) Subarachnoid hemorrhage (SAH)
Sudden deaths Sudden deaths Sudden deaths
Sudden deaths of unknown etiology Sudden deaths of unknown etiology Sudden deaths of unknown etiology
Suicide or suicide attempt Suicide or suicide attempt Suicide or suicide attempt
Systemic lupus erythematosus (SLE) Systemic lupus erythematosus (SLE) Systemic lupus erythematosus (SLE)
Thrombotic or clotting diseases Thrombotic or clotting diseases Thrombotic or clotting diseases
Thyroid condition Thyroid condition Thyroid condition
Toe walking Toe walking Toe walking
Tourette syndrome Tourette syndrome Tourette syndrome
Traumatic brain injury Traumatic brain injury Traumatic brain injury
Tremor Tremor Tremor
Unknown Unknown Unknown
Vertigo Vertigo Vertigo
Walking delays / Late acquisition of walking Walking delays / Late acquisition of walking Walking delays / Late acquisition of walking

# Definition
Type of medical condition or health related event for which the family history is taken

# Designation
Family history medical condition type

# Identifier Origin Version
FamHistMedclCondTyp BRICS Variable Name N/A
C00720 NINDS 3
3165585 NINDS caDSR N/A
pWHE47GYPUa NLM CDEs 12-02-2025-download