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1
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1
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1
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1. CN: Free of memory complaints, verified by a study partner, aside from those normal with age<br>SMC: Significant memory concern<br />EMCI/LMCI/AD: Subjective memory concern as reported by subject, study partner
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2
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2. Logical Memory II subscale score<br>CN/SMC: >=9 for 16+ years of education (ye), >=5 for 8-15ye, >=3 for 0-7ye <br>EMCI: 9-11 for 16+ye, 5-9 for 8-15ye, 3-6 for 0-7ye<br>LMCI/AD: <=8 for 16+ye, <=4 for 8-15ye, <=2 for 0-7ye
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3
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3. Mini-Mental State Exam score<br>CN/SMC/EMCI/LCMI: between 24 and 30 (inclusive)<br>AD: between 20 and 26 (inclusive)
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4
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4. Clinical Dementia Rating<br>CN/SMC= 0, Memory Box score must be 0<br>EMCI/LMCI= 0.5, Memory Box score must be at least 0.5<br>AD= 0.5
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5
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5. CN/SMC: Cognitively normal<br>EMCI/LMCI: General cognition and functional performance sufficiently preserved<br>AD: NINCDS/ADRDA criteria for probable AD
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6
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6. Stability of Permitted Medications for 4 weeks
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7
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7. Geriatric Depression Scale less than 6
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8
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8. Age between 55-90 (inclusive)
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9
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9. Study partner is available who has frequent contact with the subject (e.g., an average of 10+ hrs/wk) and can accompany the subject to all clinic visits
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10
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10. Visual and auditory acuity adequate for neuropsychological testing
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11
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11. Good general health with no diseases expected to interfere with the study
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12
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12. Subject is not pregnant, lactating
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13
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13. Willing and able to participate in a longitudinal imaging study
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14
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14. Hachinski less than
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15
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15. Sixth grade education
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16
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16. Speaks English
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17
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17. Willing and able to undergo repeated MRIs (3T) and at least two PET scans (FDG and Amyloid imaging)
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18
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18. Agrees to collection of blood for GWAS, APOE testing and DNA and RNA banking
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19
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19. Agrees to collection of blood for biomarker testing
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20
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20. Agrees to at least one lumbar puncture for the collection of CSF
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21
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1a. SMC: CCI>=16
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clinician
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clinician
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equal to 4
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equal to 4
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good work history
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good work history
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of childbearing potential
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of childbearing potential
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Spanish fluently
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Spanish fluently
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