Name Steward Organization Suggested Domain Suggested Domain Description Cde Group Classification
Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - atherothrombosis grade NINDS Disease characterization
Including Alzheimer's Disease (AD)/AD-Related Dementias (ADRD) diagnosis and multiple chronic conditions (MCCs)
NIH CDEs
  • NINDS
    • Disease
      • Stroke
        • Classification
          • Supplemental
        • Domain
          • Disease/Injury Related Events
            • Classification
    • Domain
      • Disease/Injury Related Events
        • Classification
    • Population
      • Adult

# Datatype
Value List

# Permissible value Value meaning name Value meaning definition
0 Atherosclerosis not detected. Ruling out atherosclerosis: (1) extracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-Duplex,CTA, MRA, XRA, or autopsy, (2) intracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-TCD,MRA, CTA, XRA, or autopsy, (3) aortic arch atheroma: TEE with specific assessment of the aortic arch (when the probe is pulled back at the end of the cardiac examination, turn the probe counter clockwise and take time to watch the aortic arch) or specific aortic arch assessment with CTA Atherosclerosis not detected. Ruling out atherosclerosis: (1) extracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-Duplex,CTA, MRA, XRA, or autopsy, (2) intracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-TCD,MRA, CTA, XRA, or autopsy, (3) aortic arch atheroma: TEE with specific assessment of the aortic arch (when the probe is pulled back at the end of the cardiac examination, turn the probe counter clockwise and take time to watch the aortic arch) or specific aortic arch assessment with CTA
1 Potentially causal. Atherothrombotic stroke defined as: (1) ipsilateral atherosclerotic stenosis between 50 and 99% in an intra- or extracranial artery supplying the ischemic field, or (2) ipsilateral atherosclerotic stenosis Potentially causal. Atherothrombotic stroke defined as: (1) ipsilateral atherosclerotic stenosis between 50 and 99% in an intra- or extracranial artery supplying the ischemic field, or (2) ipsilateral atherosclerotic stenosis
2 Causal link is uncertain. (1) ipsilateral atherosclerotic stenosis 30-50% in an intra- or extracranial artery supplying the ischemic field, or (2) aortic plaque =4 mm without mobile lesion Causal link is uncertain. (1) ipsilateral atherosclerotic stenosis 30-50% in an intra- or extracranial artery supplying the ischemic field, or (2) aortic plaque =4 mm without mobile lesion
3 Causal link is unlikely, but the disease is present. (1) plaque (stenosis <30%) in an intra- or extracranial artery, ipsilateral to the infarct area, (2) aortic plaque <4 mm without mobile thrombus, (3) stenosis (any degree) or occlusion in a cerebral artery not supplying the infarct area (e.g. contralateral side or opposite circulation), (4) history of myocardial infarction, coronary revascularization or peripheral arterial disease, (5) ipsi- or bilateral atherosclerotic stenosis 50–99% with bihemispheric MR-DWI lesion Causal link is unlikely, but the disease is present. (1) plaque (stenosis <30%) in an intra- or extracranial artery, ipsilateral to the infarct area, (2) aortic plaque <4 mm without mobile thrombus, (3) stenosis (any degree) or occlusion in a cerebral artery not supplying the infarct area (e.g. contralateral side or opposite circulation), (4) history of myocardial infarction, coronary revascularization or peripheral arterial disease, (5) ipsi- or bilateral atherosclerotic stenosis 50–99% with bihemispheric MR-DWI lesion
9 Incomplete workup. US-Duplex, US-TCD or CTA, or MRA, or XRA or autopsy not performed. [A minimum workup is extra- and intracranial assessment of cerebral arteries – maximum workup also includes transesophageal assessment of the aortic arch (or a default CTA of the aortic arch)] Incomplete workup. US-Duplex, US-TCD or CTA, or MRA, or XRA or autopsy not performed. [A minimum workup is extra- and intracranial assessment of cerebral arteries – maximum workup also includes transesophageal assessment of the aortic arch (or a default CTA of the aortic arch)]

# Definition
The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A).

# Designation
Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - atherothrombosis grade

# Identifier Origin Version
Ty6IuJdWrp NLM CDEs 12-02-2025-download
ASCODSystemAtherothrGrade BRICS Variable Name N/A
C58904 NINDS 1