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Active internal bleeding (<22 days)
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Active internal bleeding (<22 days)
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Active internal bleeding (<22 days)
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Advanced age
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Advanced age
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Advanced age
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Age > 80
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Age > 80
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Age > 80
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Any anticoagulant use prior to admission (even if INR < 1.7)
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Any anticoagulant use prior to admission (even if INR < 1.7)
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Any anticoagulant use prior to admission (even if INR < 1.7)
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Care-team unable to determine eligibility
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Care-team unable to determine eligibility
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Care-team unable to determine eligibility
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CT findings (ICH, SAH, or major infarct signs)
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CT findings (ICH, SAH, or major infarct signs)
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CT findings (ICH, SAH, or major infarct signs)
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CT findings of >1/3 MCA
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CT findings of >1/3 MCA
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CT findings of >1/3 MCA
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CTP not feasible
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CTP not feasible
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CTP not feasible
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Delay in Patient Arrival
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Delay in Patient Arrival
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Delay in Patient Arrival
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Delay in Stroke diagnosis
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Delay in Stroke diagnosis
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Delay in Stroke diagnosis
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Glucose < 50 or > 400 mg/dl
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Glucose < 50 or > 400 mg/dl
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Glucose < 50 or > 400 mg/dl
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History of intracranial hemorrhage or brain aneurysm or vascular malformation or brain tumor
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History of intracranial hemorrhage or brain aneurysm or vascular malformation or brain tumor
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History of intracranial hemorrhage or brain aneurysm or vascular malformation or brain tumor
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In-hospital Time Delay
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In-hospital Time Delay
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In-hospital Time Delay
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Increased risk of bleeding due to Acute pericarditis, SBE, Hemostatic defects, Diabetic hemorrhagic retinopathy, Septic thrombophlebitis/occluded AV cannula, or currently receiving oral anticoagulants
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Increased risk of bleeding due to Acute pericarditis, SBE, Hemostatic defects, Diabetic hemorrhagic retinopathy, Septic thrombophlebitis/occluded AV cannula, or currently receiving oral anticoagulants
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Increased risk of bleeding due to Acute pericarditis, SBE, Hemostatic defects, Diabetic hemorrhagic retinopathy, Septic thrombophlebitis/occluded AV cannula, or currently receiving oral anticoagulants
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IV or IA tPA given at outside hospital
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IV or IA tPA given at outside hospital
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IV or IA tPA given at outside hospital
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Left heart thrombus
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Left heart thrombus
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Left heart thrombus
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Life expectancy < 1 year or severe co-morbid illness or CMO on admission
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Life expectancy < 1 year or severe co-morbid illness or CMO on admission
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Life expectancy < 1 year or severe co-morbid illness or CMO on admission
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MRI not feasible
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MRI not feasible
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MRI not feasible
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NIHSS > 25
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NIHSS > 25
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NIHSS > 25
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No IV access
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No IV access
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No IV access
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Other, specify
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Other, specify
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Other, specify
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Patient/Family refused
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Patient/Family refused
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Patient/Family refused
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Platelets <100,000, PTT> 40 sec after heparin use, or PT > 15 or INR > 1.7, or known bleeding diathesis
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Platelets <100,000, PTT> 40 sec after heparin use, or PT > 15 or INR > 1.7, or known bleeding diathesis
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Platelets <100,000, PTT> 40 sec after heparin use, or PT > 15 or INR > 1.7, or known bleeding diathesis
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Pregnancy
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Pregnancy
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Pregnancy
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Prior Stroke and Diabetes
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Prior Stroke and Diabetes
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Prior Stroke and Diabetes
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Rapid improvement
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Rapid improvement
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Rapid improvement
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Recent intracranial or spinal surgery, head trauma, or stroke (<3 mo.)
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Recent intracranial or spinal surgery, head trauma, or stroke (<3 mo.)
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Recent intracranial or spinal surgery, head trauma, or stroke (<3 mo.)
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Recent surgery/trauma (<15 days)
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Recent surgery/trauma (<15 days)
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Recent surgery/trauma (<15 days)
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SBP > 185 or DBP > 110 mmHg despite treatment
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SBP > 185 or DBP > 110 mmHg despite treatment
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SBP > 185 or DBP > 110 mmHg despite treatment
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Seizure at onset
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Seizure at onset
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Seizure at onset
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Stroke severity - Too severe (e.g., NIHSS >22)
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Stroke severity - Too severe (e.g., NIHSS >22)
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Stroke severity - Too severe (e.g., NIHSS >22)
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Stroke severity nondisabling
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Stroke severity nondisabling
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Stroke severity nondisabling
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Subacute Bacterial Endocarditis (SBE)
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Subacute Bacterial Endocarditis (SBE)
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Subacute Bacterial Endocarditis (SBE)
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Suspicion of subarachnoid hemorrhage
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Suspicion of subarachnoid hemorrhage
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Suspicion of subarachnoid hemorrhage
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