Name Steward Organization Suggested Domain Suggested Domain Description Cde Group Classification
Health Conditions - Disease Disorders ScHARe Disease characterization
Including Alzheimer's Disease (AD)/AD-Related Dementias (ADRD) diagnosis and multiple chronic conditions (MCCs)
NIH CDEs
  • ScHARe
    • Core

# Datatype
Value List

# Permissible value Value meaning name Value meaning definition Concept Concept source
Alzheimer’s Disease Alzheimer’s Disease A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language. C2866 NCI Thesaurus
Asthma Asthma A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways. C28397 NCI Thesaurus
Autoimmune condition (e.g., rheumatoid arthritis, systemic lupus erythematosus, vasculitis) Autoimmune condition (e.g., rheumatoid arthritis, systemic lupus erythematosus, vasculitis) A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).:Used to indicate that either or both of two items or options may be valid.:A loss of any arm of immune functions, resulting in potential or actual increase in infections. This state may be reached secondary to specific genetic lesions, syndromes with unidentified or polygenic causes, acquired deficits from other disease states, or as result of therapy for other diseases or conditions. C2889 : C37998 : C14139 NCI Thesaurus
Cancer Cancer A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms usually metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin's and non-Hodgkin's lymphomas, leukemias, melanomas, and sarcomas. C9305 NCI Thesaurus
Chronic fatigue Chronic fatigue A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis. C3037 NCI Thesaurus
Chronic kidney disease Chronic kidney disease Impairment of the renal function secondary to chronic kidney damage persisting for three or more months. C80078 NCI Thesaurus
Chronic musculoskeletal condition (e.g., back pain, osteoarthritis, osteoporosis) Chronic musculoskeletal condition (e.g., back pain, osteoarthritis, osteoporosis) A doctor's order for medicine: A non-neoplastic or neoplastic disorder that affects muscles and bones. : Usually used to describe a condition that is persistent and long standing. C107377 : C14141 NCI Thesaurus
Coronary heart disease Coronary heart disease Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC) C26732 NCI Thesaurus
Dementia Dementia Loss of intellectual abilities interfering with an individual's social and occupational functions. Causes include Alzheimer's disease, brain injuries, brain tumors, and vascular disorders. C4786 NCI Thesaurus
Dental diseases and conditions (e.g., caries, periodontal disease, oral and pharyngeal cancer) Dental diseases and conditions (e.g., caries, periodontal disease, oral and pharyngeal cancer) A non-neoplastic or neoplastic (benign or malignant) disorder affecting the teeth. C35077 NCI Thesaurus
Diabetes (Type I) Diabetes (Type I) A chronic condition characterized by minimal or absent production of insulin by the pancreas. C2986 NCI Thesaurus
Diabetes (Type II) Diabetes (Type II) A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity. C26747 NCI Thesaurus
Epilepsy Epilepsy A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions. C3020 NCI Thesaurus
Eye disorders and/or diabetic eye diseases (e.g., cataract, glaucoma, amblyopia, myopia and other refractive errors, age-related macular degeneration, diabetic retinopathy, ocular trauma, uveitis, keratoconus) Eye disorders and/or diabetic eye diseases (e.g., cataract, glaucoma, amblyopia, myopia and other refractive errors, age-related macular degeneration, diabetic retinopathy, ocular trauma, uveitis, keratoconus) A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. : A group of disorders affecting the eye in patients with diabetes mellitus. It includes cataract, glaucoma, retinopathy, and blindness. C26767: C84420 NCI Thesaurus
Heart failure Heart failure Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. C50577 NCI Thesaurus
Hepatitis Hepatitis Inflammation of the liver; usually from a viral infection, but sometimes from toxic agents. C3095 NCI Thesaurus
High blood pressure/hypertension High blood pressure/hypertension Blood pressure that is abnormally high. C3117 NCI Thesaurus
High cholesterol High cholesterol An animal sterol found in the body tissues (and blood plasma) of vertebrates. It can be found in large concentrations within the liver, spinal cord, and brain. Cholesterol is an important component of the membranes of cells, providing stability. It is the major precursor for the synthesis of vitamin D, of the various steroid hormones, including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone. Cholesterol also has an important role for the brain synapses as well as in the immune system. In conditions featuring elevated low density lipoproteins (LDL), cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease.: An elevated level or position or degree; greater than normal in degree or intensity or amount. C369 : C25227 NCI Thesaurus
HIV/AIDS HIV/AIDS The virus isolated and recognized as the etiologic agent of AIDS. HIV-1 is classified as a lentivirus, a subtype of retroviruses.:An article used to connect words, phrases, or clauses representing alternatives; used to connect alternative terms for the same thing; used in correlation; used to correct or rephrase what was previously said; otherwise.:A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. C14219 : C37998 : C2851 NCI Thesaurus
Immunodeficiency Immunodeficiency Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. C3131 NCI Thesaurus
Multiple Sclerosis Multiple Sclerosis A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals. C3243 NCI Thesaurus
None of the above None of the above None of the choices above are suitable. C133298 NCI Thesaurus
Obesity Obesity Having a high amount of body fat (body mass index [BMI] of 30 or more). C3283 NCI Thesaurus
Other chronic diseases/specify Other chronic diseases/specify Different than the one(s) previously specified or mentioned.: A disease condition that persists over a significant span of time. C17649 : C165593 NCI Thesaurus
Other chronic liver disease Other chronic liver disease Different than the one(s) previously specified or mentioned.: Hepatic necrosis, inflammation, or scarring due to any cause that persists for more than 6 months. Manifestations may include signs and symptoms of cholestasis, portal hypertension, and/or abnormal liver function tests. C17649 : C113609 NCI Thesaurus
Other chronic neurological condition (e.g., Parkinson’s disease, migraine) Other chronic neurological condition (e.g., Parkinson’s disease, migraine) Different than the one(s) previously specified or mentioned.:Usually used to describe a condition that is persistent and long standing.:A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves. C17649 : C14141 : C26835 NCI Thesaurus
Other chronic respiratory disease (e.g., COPD, emphysema) Other chronic respiratory disease (e.g., COPD, emphysema) Different than the one(s) previously specified or mentioned.:Usually used to describe a condition that is persistent and long standing.:The organs that are involved in breathing. These include the nose, throat, larynx, trachea, bronchi, and lungs.: Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. C17649 : C14141 : C12779 : C2991 NCI Thesaurus
Other substance use disorder (e.g., drugs and/or alcohol dependence) Other substance use disorder (e.g., drugs and/or alcohol dependence) Different than the one(s) previously specified or mentioned.: Maladaptive pattern of drug or alcohol use that may lead to social, occupational, psychological, or physical problems.:Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. C17649 : C18272 : C2991 NCI Thesaurus
Psychological and/or psychiatric disease or disorder (e.g., anxiety, depression, bipolar disorder) Psychological and/or psychiatric disease or disorder (e.g., anxiety, depression, bipolar disorder) Having to do with how the mind works and how thoughts and feelings affect behavior.:An article used to connect words, phrases, or clauses representing alternatives; used to connect alternative terms for the same thing; used in correlation; used to correct or rephrase what was previously said; otherwise.:A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. C94316 : C37998 : C2893 NCI Thesaurus
Sickle Cell Disease Sickle Cell Disease A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia. C34383 NCI Thesaurus
Sleep disorder (e.g., insomnia, sleep apnea, narcolepsy) Sleep disorder (e.g., insomnia, sleep apnea, narcolepsy) A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep. C3376 NCI Thesaurus
Smoking Smoking The act of puffing and/or inhaling smoke from a lit cigarette, cigar, or pipe. C17934 NCI Thesaurus
Solid Organ Transplant Solid Organ Transplant An individual who is receiving a transplant of a solid organ. C130200 NCI Thesaurus
Stroke Stroke A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event. C3390 NCI Thesaurus
Thrombotic disorders Thrombotic Disorders A disorder in which there is pathological development of blood clots within the cardiovascular system. C180553 NCI Thesaurus

# Name Origin Origin Concept type
Condition NCI Thesaurus C25457 data element concept
Disease or Disorder NCI Thesaurus C2991 data element concept

# Definition Sources
A state of being, such as a state of health.C25457 | Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.C2991 NIMHD ScHARe

# Designation Tags
Health Conditions - Disease Disorders
Has a health care provider told you that you have any one or more of the following conditions? Select all that apply currently. Check the second box if you are taking medications or receiving some other treatment for the condition. Preferred Question Text

# Identifier Origin Version
hbgYw7HPpXW NLM CDEs 12-02-2025-download